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Comparing Multisert and AutonoMe.
Two different IOL injector systems, the Multisert and the AutonoMe, were used. Implantation was without critical events in 96 of 96 eyes. Mean implantation time was 41.90 ± 7.11 s with the Mult isert and 52.22 + 12.06 s with Autono me.
In lab, news, Sep 26, 2023
Introducing Dynamic Stimulation Aberrometry
The eye's reflex action of Accommodation permits us to focus on a near object and then look at a distant object. The accommodation process is impaired in presbyopic patients and may also play a role in the pathophysiology of myopia. The dynamic approach of the DSA method opens the possibility of seeing changes during the accommodation process in parallel with pupil motility.
In lab, news, , Apr 29, 2023
Recommending realistic incision sizes!
Incision size recommendations - under the microscope.
In lab, news, Feb 16, 2023
We're Recruiting!
The David J Apple Center for Vision Research is expanding. The successful candidate would conduct laboratory bench research, rheological analyses and Wet Lab surgery projects. The student researcher will become part of our research group and get the chance to gain valuable experience. There is the possibility to conduct a medical doctoral thesis after mastering the required methods.
In lab, news, Jan 23, 2023
Prize-winning AAO 2022
Gerd Auffarth received the American Academy of Ophthalmology's Life Achievement Honor Award in Chicago. He is the one European surgeon recognized by the American organisation. “CSI Heidelberg - A view from Inside” won the Grand Prize of the AAO Global Video Contest.
In lab, news, Sep 29, 2022
Merci beaucoup Philippe
Phillipe Sourdille, MD, will deliver the 1st David J. Apple MD Memorial Lecture titled “Events I Have Witnessed Over Many Years” on July 18, 2022 at the University-Eye-Clinic in Heidelberg, Germany. A fascinating journey through decades of ophthalmic research and disruptive technology.
In lab, news, Jul 18, 2022
Silicone oil drug delivery
The behavior of intravitreally applied drugs within silicone oil is not well researched. This is especially relevant in eyes with endophthalmitis that are treated with anti-infective drugs. Silicone oil, especially heavier-than-water silicone oil, may be used as a drug reservoir in the future.
In lab, news, Jul 12, 2022
Breaking news from Seoul
At this year’s APACRS Film Festival we won a prize for CSI Heidelberg- A view from inside. Now we’re heading to South Korea to film a documentary about the country. We’ll be back in a week or so to share the results with you.
In lab, news, Jun 11, 2022
Announcement: Prof. Auffarth to present the 2022 Ernst Bodenheimer Memorial Lecture.
2022 Ernst Bodenheimer Memorial Lecture: "Corneal Treatments and Surgery 2022: What We are Doing Differently" Keynote by Gerd U. Auffarth, M.D., Ph.D. of Ruprecht-Karls University of Heidelberg.
In lab, news, Apr 27, 2022
Physico-chemical parameters of Silicone Oil
The study focused on the physicochemical parameters of silicone oil after its use as an intraocular tamponade in retinal detachment surgery. The long duration does not alter the parameters of the oils within the eye, and this information further stresses the oil-aqueous interface as the prime source of emulsification.
In lab, news, Feb 06, 2022
Pupil dynamics
Pupil dynamics after in-the-bag versus anterior and retropupillary iris-fixated intraocular lens implantation. Study published in Nature’s Scientific Reports - on the effect on pupil size after three different strategies for IOL fixation. Both groups showed a smaller scotopic pupil size postoperatively, when compared to preoperative values.
In publication, lab, Nov 26, 2021
The Nuc'Cracker
“The Nuc´Cracker Suite**” was one of the award-winning videos at this year’s ESCRS congress. In this post, Dr Auerbach explains here why he made this 8 minute video and how he made it. “We wanted to present an artistic and didactic approach to cataract surgery, one where we lay out the important steps in a step-by-step sequence.”
In lab, news, Oct 10, 2021
The 80th anniversary of David Apple
Heidelberg 14 September 2021. Today would be the 80th birthday of David Joseph Apple, MD (14 September 1941, to 18 August 2011). He was the founder of our laboratory and above all he ...
In lab, history, Sep 14, 2021
Singapore winner!
Winner at the Film Festival 2021 of the Asia Pacific Association of Cataract and Refractive Surgeons in Singapore. First prize in the category, **Corneal surgery:** was awarded to **Prof. dr med.Gerd U. Auffarth for the film entitled _First clinical experiences with an artificial hydrophilic acrylic endothelial Lamellar End stage Bullous keratopathy.
In lab, news, Aug 01, 2021
Comparing preloaded IOL-injector systems
Heidelberg, 15 June 2021. We are very pleased to see our paper on the comparison of IOL-injectors published in this month’s Journal of Cataract and Refractive Surgery. In an in vitro ...
In lab, news, Jun 15, 2021
Corneal Centre to Periphery: Astigmatism Changes
Researchers looked at the corneal topography data collected by a Scheimpflug device. With-the-rule (WTR) astigmatism was the most prevalent (53%), 34% had against-the.rule (ATR), and 13% had oblique. The decrease of the cylinder power with the diameter differed significantly between the three types.
In lab, news, Apr 08, 2021
Using ANTERION® to assess IOL opacification.
Heidelberg, 29 March 2021: We are pleased to share the results of our latest study showing a morphological-functional correlation between the influence of an IOL’s localised calcifica...
In lab, news, Mar 29, 2021
Supplementary IOL calcification
Variation in IOL calcification in eyes with supplementary sulcus-supported lenses
In lab, research, Jul 27, 2020
Prizewinning work on Infra-red vision
My Master thesis “Infrared-light visibility threshold measured in diabetic and healthy patients using a two-photon ophthalmoscope” was awarded the R+H Wissenschaftspreis 2020 by the Rupp+Hubrach jury. For international readers, this is an annual Prize for science papers in the optical and ophthalmic field, which is supported by Rupp + Hubrach.
In lab, news, Jun 22, 2020
Chinese presentation
David J. Apple's presentation during the recent webinar. The PowerPoint slides are original and in English. For those who don't read Chinese, the PowerPoint slide are original. The presentation is in Chinese, but the slides are in English as well. For more information, visit: http://www.lnkd.in/d45Kyi5.
In lab, news, Jun 21, 2020
Powerlist2020: Auffarth
"The Ophthalmologist" magazine published a "Ranking" of the "100 most influential personalities in ophthalmology worldwide" This list is updated every two years, since 2014, and once again, Prof Gerd Auffarth is listed. The ranking includes not just eye surgeons but the research scientists and engineers as well as industry leaders.
In lab, news, Apr 06, 2020
Welcome 2020: New website
2019 was a great year for the Center for Vision Research in its publications of clinical and laboratory studies in peer-review journals. We look forward to seeing our partners at the ESCRS Congress this year in Amsterdam. Future content will be contributor-based. We welcome new and original articles on IOL research and IOL history.
In lab, news, Jan 01, 2020
70th IOL anniversary
Today is the 70th anniversary of the first IOL operation, Sir Harold Ridley’s implantation of an intraocular lens.
In history, lab, Nov 29, 2019
Steinbeis Center
Since 1st March 2016, all the laboratory-research, clinical-research and the curatorial work on David Apple's archive materials: all of what we do is managed within one Steinbeis Research Center: The David J Apple Center for Vision Research. The Center is part of the international Steinbe is Network of successful technology transfer groups between the sciences, academia, trade and industry.
In lab, news, Mar 01, 2016 (Archive) Welcome Patrick
Patrick Merz is a research biotechnologist with six years of experience in managing laboratory facilities both in university and in private laboratories. Dr Merz will lead the research program, manage our facility and organise resources. He is the Laboratory Leader of the David J Apple International Laboratory for Ocular Pathology.
In lab, news, May 01, 2015
Welcome
Professor Gerd Auffarth is the Professor of Ophthalmology at Heidelberg University. He worked with David Apple in the early 1990s at the Medical University of South Carolina. The lab is now housed in a thriving international laboratory for research work on intraocular devices that David initiated.
In lab, Jan 07, 2013
Why Heidelberg?
Heidelberg University is a public research university in the state of Baden-Württemberg, Germany. It dates to 1386 when Rupert I, Elector of Palatine, founded it on the instruction of Pope Urban VI. Heidelberg researchers feature prominently in the invention of the Bunsen burner and the discovery of the elements Caesium and Rubidium.
In history, lab, Oct 24, 2012
Moving to Heidelberg.
“For us, it is a great honour to be able to carry on the legacy of this great man,” says the CEO of the company. “We are proud to be part of the project,’ he adds, “and we are looking forward to working with the team.”
In lab, news, Sep 11, 2012 news
Appeal for Nepal
Harold Ridley made the first intraocular lens (IOL) on 29th November 1949. In 1967, he set up a registered charity, the **Ridley Eye Foundation (REF) which today funds cataract surgery in developing countries. The Foundation keeps a family connection – Harold Ridley's son Nicholas serves as its Chairman. In 2020, Nicholas and Alistair Wood, REF’s CEO, began an ambitious project to bring cataracts surgery to remote villages
In news, Nov 29, 2023
Comparing Multisert and AutonoMe.
Two different IOL injector systems, the Multisert and the AutonoMe, were used. Implantation was without critical events in 96 of 96 eyes. Mean implantation time was 41.90 ± 7.11 s with the Mult isert and 52.22 + 12.06 s with Autono me.
In lab, news, Sep 26, 2023 Overcoming implantation challenges with SING IMT
The SING IMT is an implantable telescope. With a haptic diameter of 10.8mm, an axial length of 4.4 mm and a weight of 63 mg in aqueous humor the implant is substantially bigger and heavier than conventional IOLs. With its increased size and weight the lens device significantly stretches the average-sized capsular bag.
In news, Aug 01, 2023
Introducing Dynamic Stimulation Aberrometry
The eye's reflex action of Accommodation permits us to focus on a near object and then look at a distant object. The accommodation process is impaired in presbyopic patients and may also play a role in the pathophysiology of myopia. The dynamic approach of the DSA method opens the possibility of seeing changes during the accommodation process in parallel with pupil motility.
In lab, news, , Apr 29, 2023 Recommending realistic incision sizes!
Incision size recommendations - under the microscope.
In lab, news, Feb 16, 2023 We're Recruiting!
The David J Apple Center for Vision Research is expanding. The successful candidate would conduct laboratory bench research, rheological analyses and Wet Lab surgery projects. The student researcher will become part of our research group and get the chance to gain valuable experience. There is the possibility to conduct a medical doctoral thesis after mastering the required methods.
In lab, news, Jan 23, 2023 Nepal Appeal
Harold Ridley made the first intraocular lens (IOL) on 29th November 1949. In 1967, he set up a registered charity, the **Ridley Eye Foundation (REF) which today funds cataract surgery in developing countries. The Foundation keeps a family connection – Harold Ridley's son Nicholas serves as its Chairman. In 2020, Nicholas and Alistair Wood, REF’s CEO, began an ambitious project to bring cataracts surgery to remote villages
In news, Nov 29, 2022 Prize-winning AAO 2022
Gerd Auffarth received the American Academy of Ophthalmology's Life Achievement Honor Award in Chicago. He is the one European surgeon recognized by the American organisation. “CSI Heidelberg - A view from Inside” won the Grand Prize of the AAO Global Video Contest.
In lab, news, Sep 29, 2022 Merci beaucoup Philippe
Phillipe Sourdille, MD, will deliver the 1st David J. Apple MD Memorial Lecture titled “Events I Have Witnessed Over Many Years” on July 18, 2022 at the University-Eye-Clinic in Heidelberg, Germany. A fascinating journey through decades of ophthalmic research and disruptive technology.
In lab, news, Jul 18, 2022 Silicone oil drug delivery
The behavior of intravitreally applied drugs within silicone oil is not well researched. This is especially relevant in eyes with endophthalmitis that are treated with anti-infective drugs. Silicone oil, especially heavier-than-water silicone oil, may be used as a drug reservoir in the future.
In lab, news, Jul 12, 2022 Platinum Performance!
The German Congress of Ophthalmic Surgeons was the largest face-to-face meeting in three years with 5,400 delegates. Four of the seven possible "Conference Best Paper Awards" went to Heidelberg researchers. Dr. Gerd U Auffarth received the first ever Platinum Medal to be awarded by DOC.
In laboratory, news, Jun 26, 2022
Breaking news from Seoul
At this year’s APACRS Film Festival we won a prize for CSI Heidelberg- A view from inside. Now we’re heading to South Korea to film a documentary about the country. We’ll be back in a week or so to share the results with you.
In lab, news, Jun 11, 2022 Announcement: Prof. Auffarth to present the 2022 Ernst Bodenheimer Memorial Lecture.
2022 Ernst Bodenheimer Memorial Lecture: "Corneal Treatments and Surgery 2022: What We are Doing Differently" Keynote by Gerd U. Auffarth, M.D., Ph.D. of Ruprecht-Karls University of Heidelberg.
In lab, news, Apr 27, 2022 Physico-chemical parameters of Silicone Oil
The study focused on the physicochemical parameters of silicone oil after its use as an intraocular tamponade in retinal detachment surgery. The long duration does not alter the parameters of the oils within the eye, and this information further stresses the oil-aqueous interface as the prime source of emulsification.
In lab, news, Feb 06, 2022 Polyimide cannulas
The polyimide cannula decreased the injection time to a quarter for all silicone oils we tested. While conventional metal cannulas failed to inject the super high-viscosity silicone oil, the Polyimide-cannula injected a clinically relevant volume in only 10 minutes. The cannulas were tested in a feasibility study in porcine cadaver eyes.
In research on silicone oil, news, Feb 06, 2022
In memory of Emanuel Rosen
Heidelberg 23 November 2021. We learn with sadness that Emanuel Rosen died on 20 November. Emanuel was a giant in UK, European and world ophthalmology. He was President of the IIIC, I...
In news, Nov 23, 2021
The Nuc'Cracker
“The Nuc´Cracker Suite**” was one of the award-winning videos at this year’s ESCRS congress. In this post, Dr Auerbach explains here why he made this 8 minute video and how he made it. “We wanted to present an artistic and didactic approach to cataract surgery, one where we lay out the important steps in a step-by-step sequence.”
In lab, news, Oct 10, 2021 Singapore winner!
Winner at the Film Festival 2021 of the Asia Pacific Association of Cataract and Refractive Surgeons in Singapore. First prize in the category, **Corneal surgery:** was awarded to **Prof. dr med.Gerd U. Auffarth for the film entitled _First clinical experiences with an artificial hydrophilic acrylic endothelial Lamellar End stage Bullous keratopathy.
In lab, news, Aug 01, 2021 Comparing preloaded IOL-injector systems
Heidelberg, 15 June 2021. We are very pleased to see our paper on the comparison of IOL-injectors published in this month’s Journal of Cataract and Refractive Surgery. In an in vitro ...
In lab, news, Jun 15, 2021 Corneal Centre to Periphery: Astigmatism Changes
Researchers looked at the corneal topography data collected by a Scheimpflug device. With-the-rule (WTR) astigmatism was the most prevalent (53%), 34% had against-the.rule (ATR), and 13% had oblique. The decrease of the cylinder power with the diameter differed significantly between the three types.
In lab, news, Apr 08, 2021 Using ANTERION® to assess IOL opacification.
Heidelberg, 29 March 2021: We are pleased to share the results of our latest study showing a morphological-functional correlation between the influence of an IOL’s localised calcifica...
In lab, news, Mar 29, 2021 IOL fixed to the capsulotomy!
The European Multicenter Trial of the IOL-Optic to the capsulotomy made by Femtosecond-Laser. We found it produced less decentration, less tilt, less rotation. We have shared the data of the trial in our open access publication in The American Journal of Ophthalmology.
In Clinical , news, Feb 27, 2021 Reversible Trifocality
Heidelberg October 2020. We are pleased to see our case report on reversible trifocality published in the October edition of the American Journal of Ophthalmology Case Reports. We pre...
In clinical, news, Dec 01, 2020
Remember 29th November!
Today, 29th November 2020, marks the 71st anniversary of the first implantation of an intraocular lens (IOL) by Sir Harold Ridley in 1949.
In news, history, Nov 29, 2020 CSI: Heidelberg. Episode 4 DMEK with EndoArt®
The EndoArt®, by EyeYon Medical, is an off-the-shelf artificial implant for partial keratoplasty. The implant works by blocking the inflow of aqueous humor into the cornea, thus reducing corneal edema. To date, two patients have received the implant, and both have performed very well.
In news, Clinical, Oct 11, 2020
4. Heidelberger Helmholtztage, 27 & 28 November
The 4th Heidelberg Helmholtz Days will take place this year as a hybrid meeting - that is both virtual and real. The official language is German. The course offers German certifications (IVOM, KRCAufbaukurse, MFAProgramm.) The program includes many current topics - faithful of course to the work of Hermann Helm holtz !!
In event, news, Oct 03, 2020
The aesthetics of iris reconstruction
Iris reconstruction with custom-made artificial iris: pupil centration and colour-matching
In laboratory, news, Aug 18, 2020
IOL sutured to an Artificial Iris - does it affect the IOL's optics?
Contributed by Dr. Hyeck-Soo Son. Heidelberg 01 August 2020. We are very pleased to see our research paper published in the Journal of Cataract and Refractive Surgery, indeed the jou...
In laboratory, news, Aug 05, 2020 Anneke Worst (1928-2020)
We extend our condolences to Erik-Jan, family, friends, and colleagues of **Anneke Worst**, the founder (with her husband Jan) of the brilliant **Ophtec** IOL company. Please visit the Ophtec site, to see their memorial to Mevr. Worst: [https://www.ophtec.com/company/news?news_id=898055]
In ophthalmology, news, Aug 04, 2020
Prizewinning work on Infra-red vision
My Master thesis “Infrared-light visibility threshold measured in diabetic and healthy patients using a two-photon ophthalmoscope” was awarded the R+H Wissenschaftspreis 2020 by the Rupp+Hubrach jury. For international readers, this is an annual Prize for science papers in the optical and ophthalmic field, which is supported by Rupp + Hubrach.
In lab, news, Jun 22, 2020 Chinese presentation
David J. Apple's presentation during the recent webinar. The PowerPoint slides are original and in English. For those who don't read Chinese, the PowerPoint slide are original. The presentation is in Chinese, but the slides are in English as well. For more information, visit: http://www.lnkd.in/d45Kyi5.
In lab, news, Jun 21, 2020 After Lock-down - how to re-start?
Cataract surgery with IOL implantation has almost stopped in most countries because of regulations to arrest the spread of COVID-19 infections. In May, in many European and Asian countries, we start to see some relaxation of these regulations. The critical question now is how do surgeons re-start clinical and surgical practices once Lock-Down Restrictions have ended?
In news, COVID 19, May 11, 2020
Powerlist2020: Auffarth
"The Ophthalmologist" magazine published a "Ranking" of the "100 most influential personalities in ophthalmology worldwide" This list is updated every two years, since 2014, and once again, Prof Gerd Auffarth is listed. The ranking includes not just eye surgeons but the research scientists and engineers as well as industry leaders.
In lab, news, Apr 06, 2020 Visualising rays in IOLs
Hyeck Soo Son, Grzegorz Labuz, Ramin Khoramnia, Patrick Merz, Timur M. Yildirim, Gerd U. Auffarth. (2020) Ray propagation imaging and optical quality evaluation of different intraocular lens models. PLOS ONE 15(2): e0228342.
In research, news, Feb 05, 2020
EDOF IOL research
The use of monochromatic light in the assessment of intraocular lenses (IOLs) has been criticized in the past for not representing the real-world situation. In our in-vitro study, we aimed to measure and compare the image quality of three extended-depth-of-focus (EDOF) IOL models. The EDOF IOLs proved more tolerant to defocus than a standard monofocal IOL.
In research , news, Jan 20, 2020
Reasons for explanting IOLs
Research team at the Apple Lab report on the demographic analysis, reasons for explantation, and material changes in intraocular lenses (IOLs) IOL opacification was the main cause for explanting in 153 (76.5%) cases. The second most common reason was IOL dislocation. Most explants were lenses from a single manufacturer.
In research, news, Jan 18, 2020
Welcome 2020: New website
2019 was a great year for the Center for Vision Research in its publications of clinical and laboratory studies in peer-review journals. We look forward to seeing our partners at the ESCRS Congress this year in Amsterdam. Future content will be contributor-based. We welcome new and original articles on IOL research and IOL history.
In lab, news, Jan 01, 2020 Wolfgang Haigis: in memoriam
Wolfgang Haigis was a physicist at the University of Wurzburg. He was instrumental in developing a device (the IOL Master) that, together with his formula is responsible for the often excellent vision that patients today enjoy with the appropriate IOL almost immediately after surgery. "His death - way too early - is a huge loss for ophthalmology," says the DGII-President.
In innovator, news, Oct 18, 2019
Small-aperture IOL results.
Heidelberg group evaluated the visual outcomes when thirteen cataract patients received a small-aperture IC-8 IOL (AcuFocus, Irvine, CA) in one eye and a segmental-refractive Lentis Mplus LS-313 IOL in the other. Five months after the operation, the mean binocular visual results demonstrated UDVA, UIVA, and UNVA values of -0.04 ± 0.11, 0.00 ± 0
In research, news, Sep 12, 2019
Straylight from glistenings
Heidelberg, 01 July 2019. The research group at the David J Apple International Laboratory for Ocular Pathology published its latest findings in this month’s edition of the renowned J...
In publication, news, Jul 01, 2019
CSI:Heidelberg Episode 2
This is the second epsiode of a series about the work done in the laboratory. In this episode we look at the interaction of the IOL with its injector. The IOL injector was developed by the German Ophthalmology Society (DOG)
In news, publication, Oct 01, 2018 Functional results and photic phenomena with Mini WELL Ready IOL
Another paper from the research group at the David J Apple Center for Vision Research has been accepted for publication in the BMC Ophthalmology journal.
In news, publication, Aug 28, 2018
Optical Quality July 1, 2018
Pars Plana Vitrectomy (PPV) – with instillation of gas into a pseudophakic eye with an acrylic hydrophilic lens – seems to increase the risk for secondary calcification irrespective of the IOL manufacturer. In these cases, IOL exchange is the only treatment option available. Using **Share Link** – a personalized URL providing free access to the article – anyone will be taken directly to the paper on ScienceDirect.
In publication, news, Jul 01, 2018 Lab at ASCRS•ASOA ANNUAL MEETING (Washington DC)
PLEASE VISIT THE APPLE LAB EXHIBIT AT BOOTH 762 AT THE 2018 ASCRS•ASOA ANNUAL MEETING. The Apple Lab will be exhibiting at the ASCRS-ASOA Annual Meeting in Las Vegas, Nevada. The event is open to the public.
In news, Apr 14, 2018 Hydrophilic acrylic IOLs and Lamellar keratoplasty
A new research article from the Apple Lab on IOL opacification after lamellar keratoplasty has been published. The research group at the David J Apple International Laboratory for Ocular Pathology today published an online research paper through [_BMC Ophthalmology_].
In news, publication, Aug 22, 2017
CSI: Heidelberg Episode 3
CSI: Heidelberg Episode 3 focuses on Multifocal and EDOF IOL technology. This is the third episode of a series about the work done in the laboratory. This time we focus onmultifocal technology. The episode will be available on iTunes and Google Play.
In news, publication, Aug 30, 2016 CSI:Heidelberg Episode 1
The Winner - Best Video at the annual meeting of ESCRS 2018 in Vienna. This is the first epsiode of a series about the work done in the laboratory. The first video was shot in a CSI: Crime Scene Investigation style. The video series informs the viewer how we operate.
In news, publication, Aug 30, 2016 (ARCHIVE) Welcome Lucia
Lucia Poggi is a Cell Biology Leader at the David J Apple International Laboratory for Ocular Pathology. Her current research interests focus on understanding the in-vivo cell biology of asymmetric cell division and fate identity acquisition during ocular development and regeneration. She received her MSc and PhD from the University of Pisa, Italy. She established methods of cellular-resolution microscopy to directly observe individual retinal stem cells.
In staff, news, Jul 15, 2016
(ARCHIVE) Welcome Sonja
Dr Sonja Schickhardt will lead the research program, manage our facility and organize its resources. She is an organic chemist with experience in managing laboratory facilities and recently in building research links and transfers between University and Industry. The David J Apple International Laboratory for Ocular Pathology is based in Berlin, Germany.
In staff, news, Jul 01, 2016
2016 Heidelberg Helmholtz Symposium
The second in a series of annual symposia: featuring workshops and presentations on contemporary topics in ophthalmology. All didactic sessions are in the German language. The Programme will be made available in September 2016. The 2016 Heidelberg Helmholtz Symposium by The David J Apple Center for Vision Research.
In news, Jun 29, 2016 Steinbeis Center
Since 1st March 2016, all the laboratory-research, clinical-research and the curatorial work on David Apple's archive materials: all of what we do is managed within one Steinbeis Research Center: The David J Apple Center for Vision Research. The Center is part of the international Steinbe is Network of successful technology transfer groups between the sciences, academia, trade and industry.
In lab, news, Mar 01, 2016 Albert Galand 1938 - 2015.
Albert Galand was born 29 October 1938 in Woluwe-Saint-Lambert (Brussels) and died 22 December 2015 in Liege, Belgium. He was a pioneer in capsular IOL design and intra-capsular techniques. His inventions in lens design in the 1990s were quickly picked up by European companies.
In pioneer, news, Jan 06, 2016 Seasonal greetings
We wish all the clients and friends of the Apple Lab a very Merry Christmas and a Peaceful, Prosperous and Healthy New Year. We look forward to working with you in 2016. Merry Christmas. ## Merry Christmas and a Happy New Year! We wish you all a Merry Christmas!
In news, Dec 23, 2015 New Look for the Lab
In October the main laboratory room of the Apple Lab was refurbished. The room is now customised to carry out our main work on measuring and examining intraocular lenses. The Leader of the laboratory, Dr Patrick Merz welcomed the change. Later this year we will complete the project by installing more equipment in the lab.
In news, Nov 02, 2015
Jan Worst 1928 to 2015
Jan Worst was a pioneer of intraocular lens design and co-founder of the Ophtec IOL-manufacturing company. He died in Groningen in The Netherlands on 25th September 2015. He was one of the pioneers in IOL Development and a most influential innovator.
In pioneer, news, Oct 01, 2015 (Archive) Welcome Patrick
Patrick Merz is a research biotechnologist with six years of experience in managing laboratory facilities both in university and in private laboratories. Dr Merz will lead the research program, manage our facility and organise resources. He is the Laboratory Leader of the David J Apple International Laboratory for Ocular Pathology.
In lab, news, May 01, 2015 Opacification after rTPA
Intraocular Lens Opacification following Intracameral Injection of Recombinant Tissue Plasminogen Activator to Treat Inflammatory Membranes after Cataract Surgery. The research group at the David J Apple International Laboratory for Ocular Pathology published a research paper in the Journal of Ophthalmology.
In news, publication, Mar 18, 2015 DGII Award for Mary Attia
Dr Mary Safwat Aziz Attia won the award for ‘Best Paper of the Session’ in the Scientific Sessions on Multifocal IOLs. The award was made at the 29th annual meeting of the German-speaking Society of Intraocular Lens Implantation, Interventional and Refractive Surgery. Dr Attia has been carrying out research in the Heidelberg Eye Department and the Apple Lab since June 2013.
In research, news, Mar 11, 2015
Feast for Eye and Ear
Prof. Gerd Auffarth, Head of the DJApple Lab and Chairman of the University Clinic Eye Department drew a record audience of 730 to his “Medicine in the Evening’ lecture on ophthalmology. The lectures are sponsored by the local Heidelberg newspaper **Rhein Neckar Zeitung**.
In news, Jan 25, 2015
The Ridleys visit the Lab
Nicholas and Lauretta Ridley visited the David J Apple Laboratory and met with some of the staff and directors of the laboratory. Nicholas had an attempt at cataract surgery using the laboratory’s phaco simulator and he remarked afterwards “he had not inherited his father's surgical dexterity!’
In news, Dec 22, 2014 Boston ASCRS.
Dr. Ramin Khoramnia MD FEBO won Runner-Up prize in the category, Cataract Complications, with the film ‘CSI: Heidelberg-IOL Analysis’ The film was made under the supervision of Prof Gerd Auffarth. It reports research work that Dr KhorAmnia and his colleagues at the Apple Lab have done in analysing intraocular lenses.
In news, Apr 30, 2014 Better vision for AMD patients.
Oculentis Lentis Mplus High Add IOL is a hydrophobic acrylic biconvex IOL which has a +8 D sector-shaped near addition resulting in 6 D of near correction at the spectacle plane and 1.5 times magnifying power. “It provides image magnification for near — quite useful for AMD patients who normally have to rely on low vision reading aids such as magnifying glasses or electronic reading desks,” Prof. Gerd U.
In clinical, news, Apr 03, 2014 Congratulations, Ramin!
Ramin Khoramnia,** Research Fellow from The Apple Lab came second overall in the European Board of Ophthalmology’s 2013 classification of 440 examination candidates. It is very important for European doctors to have a European degree these days, because European thinking is becoming more and more important.
In staff, news, Aug 29, 2013 The Legend of Albert Schweitzer
Albert Schweitzer (1875 – 1965) was multi-talented: a theologian, a doctor of medicine, a church organist, philosopher, pacifist and a philanthropist. Schweitzer committed his life to this work. We must keep these ideals in mind as we build and develop the David Apple Laboratory in Heidelberg.
In news, Feb 22, 2013
Crossing an Ocean – the laboratory that moved
Last year, the Laboratory moved from Charleston South Carolina to University Eye Department of the University of Heidelberg. The intention is to create an international laboratory for research on intraocular ophthalmic devices. All of Professor Apple’s archives, historical laboratory samples and correspondence are housed.
In news, Nov 02, 2012 Moving to Heidelberg.
“For us, it is a great honour to be able to carry on the legacy of this great man,” says the CEO of the company. “We are proud to be part of the project,’ he adds, “and we are looking forward to working with the team.”
In lab, news, Sep 11, 2012 history
The 80th anniversary of David Apple
Heidelberg 14 September 2021. Today would be the 80th birthday of David Joseph Apple, MD (14 September 1941, to 18 August 2011). He was the founder of our laboratory and above all he ...
In lab, history, Sep 14, 2021 Remember 29th November!
Today, 29th November 2020, marks the 71st anniversary of the first implantation of an intraocular lens (IOL) by Sir Harold Ridley in 1949.
In news, history, Nov 29, 2020 70th IOL anniversary
Today is the 70th anniversary of the first IOL operation, Sir Harold Ridley’s implantation of an intraocular lens.
In history, lab, Nov 29, 2019 A Lab with history
The origin of the David J Apple International Laboratory for Ocular Pathology goes back to the establishment in 1980 by David Apple and Randall J. Olson MD of a pathology laboratory i...
In history, Aug 01, 2013
Why Heidelberg?
Heidelberg University is a public research university in the state of Baden-Württemberg, Germany. It dates to 1386 when Rupert I, Elector of Palatine, founded it on the instruction of Pope Urban VI. Heidelberg researchers feature prominently in the invention of the Bunsen burner and the discovery of the elements Caesium and Rubidium.
In history, lab, Oct 24, 2012 staff
(ARCHIVE) Welcome Lucia
Lucia Poggi is a Cell Biology Leader at the David J Apple International Laboratory for Ocular Pathology. Her current research interests focus on understanding the in-vivo cell biology of asymmetric cell division and fate identity acquisition during ocular development and regeneration. She received her MSc and PhD from the University of Pisa, Italy. She established methods of cellular-resolution microscopy to directly observe individual retinal stem cells.
In staff, news, Jul 15, 2016 (ARCHIVE) Welcome Sonja
Dr Sonja Schickhardt will lead the research program, manage our facility and organize its resources. She is an organic chemist with experience in managing laboratory facilities and recently in building research links and transfers between University and Industry. The David J Apple International Laboratory for Ocular Pathology is based in Berlin, Germany.
In staff, news, Jul 01, 2016 Congratulations, Ramin!
Ramin Khoramnia,** Research Fellow from The Apple Lab came second overall in the European Board of Ophthalmology’s 2013 classification of 440 examination candidates. It is very important for European doctors to have a European degree these days, because European thinking is becoming more and more important.
In staff, news, Aug 29, 2013 clinical
Reversible Trifocality
Heidelberg October 2020. We are pleased to see our case report on reversible trifocality published in the October edition of the American Journal of Ophthalmology Case Reports. We pre...
In clinical, news, Dec 01, 2020 Better vision for AMD patients.
Oculentis Lentis Mplus High Add IOL is a hydrophobic acrylic biconvex IOL which has a +8 D sector-shaped near addition resulting in 6 D of near correction at the spectacle plane and 1.5 times magnifying power. “It provides image magnification for near — quite useful for AMD patients who normally have to rely on low vision reading aids such as magnifying glasses or electronic reading desks,” Prof. Gerd U.
In clinical, news, Apr 03, 2014 research
Supplementary IOL calcification
Variation in IOL calcification in eyes with supplementary sulcus-supported lenses
In lab, research, Jul 27, 2020 Visualising rays in IOLs
Hyeck Soo Son, Grzegorz Labuz, Ramin Khoramnia, Patrick Merz, Timur M. Yildirim, Gerd U. Auffarth. (2020) Ray propagation imaging and optical quality evaluation of different intraocular lens models. PLOS ONE 15(2): e0228342.
In research, news, Feb 05, 2020 Reasons for explanting IOLs
Research team at the Apple Lab report on the demographic analysis, reasons for explantation, and material changes in intraocular lenses (IOLs) IOL opacification was the main cause for explanting in 153 (76.5%) cases. The second most common reason was IOL dislocation. Most explants were lenses from a single manufacturer.
In research, news, Jan 18, 2020 Small-aperture IOL results.
Heidelberg group evaluated the visual outcomes when thirteen cataract patients received a small-aperture IC-8 IOL (AcuFocus, Irvine, CA) in one eye and a segmental-refractive Lentis Mplus LS-313 IOL in the other. Five months after the operation, the mean binocular visual results demonstrated UDVA, UIVA, and UNVA values of -0.04 ± 0.11, 0.00 ± 0
In research, news, Sep 12, 2019 Light scattering
The latest scientific research paper from the research group at the David J Apple Lab has been accepted for publication in the prestigious American Journal of Ophthalmology. The Kowa IOL had no glistenings. IOL manufacturers still need to address the problem through either introduction of new materials or by continuous improvement of the manufacturing process.
In research, publication, Sep 14, 2018 DGII Award for Mary Attia
Dr Mary Safwat Aziz Attia won the award for ‘Best Paper of the Session’ in the Scientific Sessions on Multifocal IOLs. The award was made at the 29th annual meeting of the German-speaking Society of Intraocular Lens Implantation, Interventional and Refractive Surgery. Dr Attia has been carrying out research in the Heidelberg Eye Department and the Apple Lab since June 2013.
In research, news, Mar 11, 2015 publication
Pupil dynamics
Pupil dynamics after in-the-bag versus anterior and retropupillary iris-fixated intraocular lens implantation. Study published in Nature’s Scientific Reports - on the effect on pupil size after three different strategies for IOL fixation. Both groups showed a smaller scotopic pupil size postoperatively, when compared to preoperative values.
In publication, lab, Nov 26, 2021 Straylight from glistenings
Heidelberg, 01 July 2019. The research group at the David J Apple International Laboratory for Ocular Pathology published its latest findings in this month’s edition of the renowned J...
In publication, news, Jul 01, 2019 CSI:Heidelberg Episode 2
This is the second epsiode of a series about the work done in the laboratory. In this episode we look at the interaction of the IOL with its injector. The IOL injector was developed by the German Ophthalmology Society (DOG)
In news, publication, Oct 01, 2018 Light scattering
The latest scientific research paper from the research group at the David J Apple Lab has been accepted for publication in the prestigious American Journal of Ophthalmology. The Kowa IOL had no glistenings. IOL manufacturers still need to address the problem through either introduction of new materials or by continuous improvement of the manufacturing process.
In research, publication, Sep 14, 2018 Functional results and photic phenomena with Mini WELL Ready IOL
Another paper from the research group at the David J Apple Center for Vision Research has been accepted for publication in the BMC Ophthalmology journal.
In news, publication, Aug 28, 2018 EDOF wavelength dependence
The latest paper from the David J Apple Lab has been accepted for future publication in the influential American Journal of Ophthalmology. In vitro analysis confirmed Symfony’s wavelength dependence: performance was improved at a far distance but was worse at intermediate and near distances. Although the red filter did not improve distance vision, it caused visual deterioration at the near distance.
In publication, Aug 19, 2018 Optical Quality July 1, 2018
Pars Plana Vitrectomy (PPV) – with instillation of gas into a pseudophakic eye with an acrylic hydrophilic lens – seems to increase the risk for secondary calcification irrespective of the IOL manufacturer. In these cases, IOL exchange is the only treatment option available. Using **Share Link** – a personalized URL providing free access to the article – anyone will be taken directly to the paper on ScienceDirect.
In publication, news, Jul 01, 2018 A dip into our Archives
From the ASCRS meeting in 2011 – a PowerPoint presentation on **Visualized light paths in different multifocal intraocular lenses. The slide was part of a larger presentation on the use of light-paths in multifocal lenses. Click here to read the rest of the slide.
In publication, Sep 07, 2017 Hydrophilic acrylic IOLs and Lamellar keratoplasty
A new research article from the Apple Lab on IOL opacification after lamellar keratoplasty has been published. The research group at the David J Apple International Laboratory for Ocular Pathology today published an online research paper through [_BMC Ophthalmology_].
In news, publication, Aug 22, 2017 CSI: Heidelberg Episode 3
CSI: Heidelberg Episode 3 focuses on Multifocal and EDOF IOL technology. This is the third episode of a series about the work done in the laboratory. This time we focus onmultifocal technology. The episode will be available on iTunes and Google Play.
In news, publication, Aug 30, 2016 CSI:Heidelberg Episode 1
The Winner - Best Video at the annual meeting of ESCRS 2018 in Vienna. This is the first epsiode of a series about the work done in the laboratory. The first video was shot in a CSI: Crime Scene Investigation style. The video series informs the viewer how we operate.
In news, publication, Aug 30, 2016 Opacification after rTPA
Intraocular Lens Opacification following Intracameral Injection of Recombinant Tissue Plasminogen Activator to Treat Inflammatory Membranes after Cataract Surgery. The research group at the David J Apple International Laboratory for Ocular Pathology published a research paper in the Journal of Ophthalmology.
In news, publication, Mar 18, 2015 pioneer
Albert Galand 1938 - 2015.
Albert Galand was born 29 October 1938 in Woluwe-Saint-Lambert (Brussels) and died 22 December 2015 in Liege, Belgium. He was a pioneer in capsular IOL design and intra-capsular techniques. His inventions in lens design in the 1990s were quickly picked up by European companies.
In pioneer, news, Jan 06, 2016 Jan Worst 1928 to 2015
Jan Worst was a pioneer of intraocular lens design and co-founder of the Ophtec IOL-manufacturing company. He died in Groningen in The Netherlands on 25th September 2015. He was one of the pioneers in IOL Development and a most influential innovator.
In pioneer, news, Oct 01, 2015 innovator
Wolfgang Haigis: in memoriam
Wolfgang Haigis was a physicist at the University of Wurzburg. He was instrumental in developing a device (the IOL Master) that, together with his formula is responsible for the often excellent vision that patients today enjoy with the appropriate IOL almost immediately after surgery. "His death - way too early - is a huge loss for ophthalmology," says the DGII-President.
In innovator, news, Oct 18, 2019 research
EDOF IOL research
The use of monochromatic light in the assessment of intraocular lenses (IOLs) has been criticized in the past for not representing the real-world situation. In our in-vitro study, we aimed to measure and compare the image quality of three extended-depth-of-focus (EDOF) IOL models. The EDOF IOLs proved more tolerant to defocus than a standard monofocal IOL.
In research , news, Jan 20, 2020 News
Congratulations Max!
Maximilian Hammer, a research student working in our team at the David J Apple Lab, has won the 2020 MLP Medical Excellence Scholarship. Max began his medical studies at Heidelberg University in 2016. He is currently mainly working on projects on the emulsification of silicone oils used as intraocular endotamponades.
In Laboratory, News, Nov 26, 2020 
COVID 19
After Lock-down - how to re-start?
Cataract surgery with IOL implantation has almost stopped in most countries because of regulations to arrest the spread of COVID-19 infections. In May, in many European and Asian countries, we start to see some relaxation of these regulations. The critical question now is how do surgeons re-start clinical and surgical practices once Lock-Down Restrictions have ended?
In news, COVID 19, May 11, 2020 ophthalmology
Anneke Worst (1928-2020)
We extend our condolences to Erik-Jan, family, friends, and colleagues of **Anneke Worst**, the founder (with her husband Jan) of the brilliant **Ophtec** IOL company. Please visit the Ophtec site, to see their memorial to Mevr. Worst: [https://www.ophtec.com/company/news?news_id=898055]
In ophthalmology, news, Aug 04, 2020 laboratory
Platinum Performance!
The German Congress of Ophthalmic Surgeons was the largest face-to-face meeting in three years with 5,400 delegates. Four of the seven possible "Conference Best Paper Awards" went to Heidelberg researchers. Dr. Gerd U Auffarth received the first ever Platinum Medal to be awarded by DOC.
In laboratory, news, Jun 26, 2022 The aesthetics of iris reconstruction
Iris reconstruction with custom-made artificial iris: pupil centration and colour-matching
In laboratory, news, Aug 18, 2020 IOL sutured to an Artificial Iris - does it affect the IOL's optics?
Contributed by Dr. Hyeck-Soo Son. Heidelberg 01 August 2020. We are very pleased to see our research paper published in the Journal of Cataract and Refractive Surgery, indeed the jou...
In laboratory, news, Aug 05, 2020 Clinical
CSI: Heidelberg. Episode 4 DMEK with EndoArt®
The EndoArt®, by EyeYon Medical, is an off-the-shelf artificial implant for partial keratoplasty. The implant works by blocking the inflow of aqueous humor into the cornea, thus reducing corneal edema. To date, two patients have received the implant, and both have performed very well.
In news, Clinical, Oct 11, 2020 event
4. Heidelberger Helmholtztage, 27 & 28 November
The 4th Heidelberg Helmholtz Days will take place this year as a hybrid meeting - that is both virtual and real. The official language is German. The course offers German certifications (IVOM, KRCAufbaukurse, MFAProgramm.) The program includes many current topics - faithful of course to the work of Hermann Helm holtz !!
In event, news, Oct 03, 2020 Laboratory
Congratulations Max!
Maximilian Hammer, a research student working in our team at the David J Apple Lab, has won the 2020 MLP Medical Excellence Scholarship. Max began his medical studies at Heidelberg University in 2016. He is currently mainly working on projects on the emulsification of silicone oils used as intraocular endotamponades.
In Laboratory, News, Nov 26, 2020 Research
Glistening through the years
Heidelberg, 5 February, 2021. We are pleased to report that our latest research paper is published today in the Ophthalmology and Therapy journal: Quantification of the In Vitro Predi...
In Research, History, Feb 05, 2021
History
Glistening through the years
Heidelberg, 5 February, 2021. We are pleased to report that our latest research paper is published today in the Ophthalmology and Therapy journal: Quantification of the In Vitro Predi...
In Research, History, Feb 05, 2021 Clinical
IOL fixed to the capsulotomy!
The European Multicenter Trial of the IOL-Optic to the capsulotomy made by Femtosecond-Laser. We found it produced less decentration, less tilt, less rotation. We have shared the data of the trial in our open access publication in The American Journal of Ophthalmology.
In Clinical , news, Feb 27, 2021 research on silicone oil
Polyimide cannulas
The polyimide cannula decreased the injection time to a quarter for all silicone oils we tested. While conventional metal cannulas failed to inject the super high-viscosity silicone oil, the Polyimide-cannula injected a clinically relevant volume in only 10 minutes. The cannulas were tested in a feasibility study in porcine cadaver eyes.
In research on silicone oil, news, Feb 06, 2022 Introducing Dynamic Stimulation Aberrometry
The eye's reflex action of Accommodation permits us to focus on a near object and then look at a distant object. The accommodation process is impaired in presbyopic patients and may also play a role in the pathophysiology of myopia. The dynamic approach of the DSA method opens the possibility of seeing changes during the accommodation process in parallel with pupil motility.
In lab, news, , Apr 29, 2023 lab news
DOG 2023 -Group Photo
The German Society of Ophthalmology unites over 8.000 ophthalmologists in hospitals, medical- and research-centers, including Heidleberg's David J Apple Center for Vision Research. The society's annual congress is held in Berlin every year.
In lab news, Sep 29, 2023
APACRS LIM Lecture
The lecture is named after Arthur Lim (1934-2014), the father of ophthalmology in Singapore. He was founding medical director of the Singapore National Eye Centre. He also helped establish the Singapore Eye Research Institute. Among his contributions are more than 20 books, including a comprehensive guide to eye diseases.
In lab news, Aug 12, 2023
Enlarged incisions – but why?
In cataract surgery small corneal incisions are associated with a significantly better visual recovery. What are initially small incisions can enlarge during surgery and that impedes the positive effects of keeping the incision small. Our goal was to identify the surgical factors that cause a larger final incision size. We can recommend that IOL-manufacturers should reduce the vertical diameter of the injector tip.
In lab news, Jun 29, 2023
DOC23 Success
Leonie Britz and Max Hammer each won a “Best Paper of Session" Award for their lectures at the DOC Congress in Nuremberg. Well done and congratulations to you both. Gerd U Auffarth MD, PhD, FEBO, DJ Apple Laboratory.
In lab news, Jun 20, 2023
clinical news
The safety of Reversible Trifocality.
The long-term axial alignment of capsular bag–fixated toric IOLs in polypseudophakic eyes was comparable to the results reported for monopseudophaks. The presence of the second lens in the sulcus did not appear to affect the rotational stability of the first IOL.
In clinical news, Oct 14, 2023
Silicone oIl study
Oil and Lenses don't mix
Heidelberg, 23 November 2023, we are very pleased to see in the latest American Journal of Ophthalmology our paper published on our experimental study examining straylight from oil dr...
In Silicone oIl study, Nov 26, 2023
Featured
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Oil and Lenses don't mix
In Silicone oIl study, -
The safety of Reversible Trifocality.
In clinical news, -
DOG 2023 -Group Photo
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Comparing Multisert and AutonoMe.
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APACRS LIM Lecture
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Overcoming implantation challenges with SING IMT
In news, -
Enlarged incisions – but why?
In lab news, -
DOC23 Success
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Introducing Dynamic Stimulation Aberrometry
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Two Apple cores
In news, history, -
We're Recruiting!
In lab, news, -
Merci beaucoup Philippe
In lab, news, -
Why Heidelberg?
In history, lab,