Heidelberg, 20 May 2025. We are pleased to report that our paper, which communicates the results of our assessment of two hybrid refractive-diffractive IOLs with enhanced depth of focus, is now accessible online. It appears in this month’s edition of the Clinical Ophthalmology journal.
Baur ID, Khoramnia R, Son HS, Auffarth GU, Łabuz G. Ray Visualization and Through-Focus Optical Quality of Diffractive Enhanced Monofocal and Extended-Depth-of-Focus Intraocular Lenses. Clin Ophthalmol. 2025;19:1673-1682
https://doi.org/10.2147/OPTH.S520086
Our objective:
In an in vitro study, we compared two hybrid refractive-diffractive IOLs with enhanced depth of focus. We assessed the lens optical quality in monochromatic and polychromatic light as well as their ray-propagation behaviour.
Figure 1 (A) Shows drawings of the xact Mono-EDoF IOL and (B) of the Symfony IOL. The arrows indicate the diffractive rings of each IOL model. (C) shows a surface image of the xact Mono-EDoF and (D) a surface image of the Symfony IOL.
Which lens models?
We examined two intraocular lens (IOL) models, the exact Mono-EDoF ME4 IOL (Santen Pharmaceutical, Osaka, Japan) and the Tecnis Symfony ZXR00 IOL (Johnson & Johnson Vision, Irvine, USA), measuring the through focus (TF) modulation transfer function (MTF) using monochromatic green (546 nm) and polychromatic light at different spatial frequencies. We performed Ray propagation imaging using monochromatic green light (520 nm) projected through each IOL while the lens was submerged in a bath of fluorescein solution. The visual pathways images were captured by a camera mounted on a microscope. To aid comparison, we created a ray visualisation for a monofocal control lens, the W60-R IOL (Santen Pharmaceutical, Osaka, Japan).
What were the results:
The exact Mono-EDoF IOL showed superior TF-MTF performance for defocus of up to − 1.3D compared to the Symfony IOL in monochromatic and polychromatic light. For higher defocus values, however, the Symfony showed superior performance than the exact Mono-EDoF. Image quality in polychromatic light decreased for both IOLs compared to monochromatic light.
Figure 2 Through-focus MTF curves of the two IOL models under monochromatic and polychromatic light conditions at different spatial frequencies. The data labelled as “Mono-EDoF” refers to the xact Mono-EDoF ME4 and the data labelled as “Symfony” refer to the Symfony ZXR00 IOL.
Ray propagation imaging revealed one distinct focus for the monofocal control lens. The exact Mono-EDoF demonstrated an elongated focus area. The Symfony showed two focal points.
Figure 3 Ray propagation and light intensity profiles of a monofocal IOL (upper row), the Mono-EDoF (middle row) and the Symfony (bottom row).
What can we conclude?
We found comparable deterioration of image quality in polychromatic light for both IOLs with improved intermediate range. The Mono-EDoF demonstrated an elongated focus and superior TF-MTF performance at lower defocus values, but it did not match the standard EDoF model at higher defocus.
Access the paper.
Here is the access link: (https://www.dovepress.com/articles.php?article_id=103126.).
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